Welcome to DU! The truly grassroots left-of-center political community where regular people, not algorithms, drive the discussions and set the standards. Join the community: Create a free account Support DU (and get rid of ads!): Become a Star Member Latest Breaking News Editorials & Other Articles General Discussion The DU Lounge All Forums Issue Forums Culture Forums Alliance Forums Region Forums Support Forums Help & Search

NNadir

(34,676 posts)
4. Almost all modern toxicological work begins with cell based assays, as do many screens for therapeutic value.
Mon Jan 1, 2024, 07:53 PM
Jan 2024

I agree that one can always expand upon cell work, and one should do so, although there is a very active movement to minimize animal studies by substituting, beyond cells, tissues.

This said there is some epidemiological reference in the full paper describing - as alluded in my excerpt - to higher rates of CRC among people how have high levels of exposure to PFAS, notably firefighters with exposure to PFAS based AFFF.

If funded, it may be possible to compare CRC patients, particularly those with KRAS oncogenes for serum or plasma levels of PFAS with a control group.

There are many thousands of studies in the literature on PFAS levels in human and animal tissue.

Latest Discussions»Culture Forums»Science»The Effect of PFAS on Col...»Reply #4