1. The company planning the pipeline has a history of accidents that have caused death and injuries (for instance: http://usnews.nbcnews.com/_news/2013/06/13/18936624-one-dead-scores-injured-in-louisiana-chemical-plant-explosion?lite), environmental degradation (groundwater and soil contamination in Colorado - can't find the link right now), and evacuations (for instance: http://www.wutc.wa.gov/webimage.nsf/d7506612dc95c1928825657200770590/f658498d2f5a207888256d1a0058cc3f!OpenDocument).
2. I am opposed to fracking in general because of it's environmental impact. Money required to build a multistate pipeline would be better spent on renewable resources. And yes, renewable resources also have downsides and environmental costs, but I think they are better than those associated with fossil fuels and especially fracking.
3. Landowners in KY assume risks and disturbance to their land (along with lower property values) but get nothing in return. The gas is being sent to exporters and very little if any will be used domestically. Even the jobs will primarily be based out of state.
These are the primary reasons I'm opposed to the pipeline. I might come up with more if I give it some more thought.
= new reply since forum marked as read