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intrepidity

(8,549 posts)

30. Some nerd details

Wed Mar 18, 2020, 09:53 AM

Mar 2020

Avigan functions as an antiviral drug against RNA viruses. Yousuke Furuta, a researcher at Toyama Chemical research laboratories, has said in a report that Avigan selectively inhibits the RNA-dependent RNA polymerase (RdRp) of RNA viruses. Avigan undergoes an intracellular phosphoribosylation to become an active form and then inhibits RNA polymerase activity.

As the catalytic domain of RdRp is conserved among various types of RNA viruses, that mechanism of action supports a wide spectrum of potential activity. Avigan works against a broad range of influenza virus types as well as West Nile virus, yellow fever, foot-and-mouth disease, and other flaviviruses, arenaviruses, bunyaviruses and alphaviruses, he noted.

https://www.bioworld.com/articles/433290-fujifilm-stock-rises-as-japan-considers-avigan-for-covid-19-treatment

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Japanese flu drug 'clearly effective' in treating coronavirus, says China. From The Guardian... [View all] abqtommy Mar 2020 OP

Give it to us for free, even though we have a president that was plotting to hold you hostage with brewens Mar 2020 #1

I'd be willing to pay a fair market price but you know tRUMP has to get his cut... abqtommy Mar 2020 #2

How long for a new drug to get FDA approval? (n/t) Spider Jerusalem Mar 2020 #3

We have a model for this, from the HIV pandemic. Need to shortcut the process. lagomorph777 Mar 2020 #15

spread the rumor it's a liberal plot, turns people into zombies - half the trumpers will refuse it certainot Mar 2020 #26

If you really want to scare them off tell them it will turn their skin brown. Alwaysna Mar 2020 #29

brown zombies! certainot Mar 2020 #33

Immediate approval for the rich, everyone else?...who knows. C Moon Mar 2020 #45

:D C Moon Mar 2020 #44

It was already being looked at and there is data for use in Rift Valley Fever--a zoonotic viral hlthe2b Mar 2020 #4

Kicking it up. Thank you. Guilded Lilly Mar 2020 #5

This message was self-deleted by its author democratisphere Mar 2020 #6

Anyone more interested in the drug can start here: Act_of_Reparation Mar 2020 #7

it is a pyrazinecarboxamide derivative. progressoid Mar 2020 #9

Pyraznamide has a similar effect on mycobacteria. Act_of_Reparation Mar 2020 #21

This seems huge. Wonder how big their stockpile is, and when they can ramp it up? lostnfound Mar 2020 #8

They can license it videohead5 Mar 2020 #10

This gives me hope. Silver Gaia Mar 2020 #11

That is encouraging news! kentuck Mar 2020 #12

I hope this is solid. Girard442 Mar 2020 #13

drumpf will never go for this, he's got his huge profits already planned. lark Mar 2020 #14

SO don't let him have any. The country needs to rise up if he pulls any more shit like that. lagomorph777 Mar 2020 #16

He's already doing it with the testing and got caught doing this w/the vaccine. lark Mar 2020 #17

They will pay. The Grovelers Of Putin will be cast out like lepers (the way they'd treat lepers). lagomorph777 Mar 2020 #18

I so hope you are right catchnrelease Mar 2020 #38

Feed them Roundup. lagomorph777 Mar 2020 #39

Good idea catchnrelease Mar 2020 #40

Kick and recommend for hope! bronxiteforever Mar 2020 #19

Good news! crickets Mar 2020 #20

Good news! worth watching. bluestarone Mar 2020 #22

KnR SammyWinstonJack Mar 2020 #23

Good news if true... Wounded Bear Mar 2020 #24

yep SCantiGOP Mar 2020 #25

The Guardian is usually pretty good... Wounded Bear Mar 2020 #27

Oh, I agree SCantiGOP Mar 2020 #28

Getting a little sick of the China hate. Sad to see it here too. AtheistCrusader Mar 2020 #43

China stifled their whistle-blower in the early days (he eventually died of the bug) FiveGoodMen Mar 2020 #46

I don't view that as a matter of 'honesty'. It's central planning. AtheistCrusader Mar 2020 #47

Some nerd details intrepidity Mar 2020 #30

Here is another similar hope from France.. pangaia Mar 2020 #31

Nice. And Azithromycin is available by the bucket load too, cheap. AtheistCrusader Mar 2020 #48

Speaking of Azithromycin.. pangaia Mar 2020 #50

I've had it work a few times. AtheistCrusader Mar 2020 #51

People here seem to be overly optimistic about this. It would not make the problem go away. thesquanderer Mar 2020 #32

Sooner is better, for lethality. AtheistCrusader Mar 2020 #49

Seems it only works for people who were tested early on. Temper enthusiasm Roland99 Mar 2020 #34

How does someone turn 'Negative" after they tested positive? I thought they tested Maraya1969 Mar 2020 #35

You would think that every shuttered business would be live love laugh Mar 2020 #36

K & R SunSeeker Mar 2020 #37

Considering the orange shit for brains MyNameGoesHere Mar 2020 #41

I would want more tests from other places rockfordfile Mar 2020 #42

K and R dewsgirl Mar 2020 #52

Gohmert's asking Grokenstein Mar 2020 #53

It only works in early cases. In US we only test in the ICU McCamy Taylor Mar 2020 #54

Encouraging to see China and Japan working together. Fla Dem Mar 2020 #55

This is good news. Aussie105 Mar 2020 #56

trump will make stumbling blocks to inhibit its introduction Demonaut Mar 2020 #57

Other Incouraging Treatments Being Tested Right Now DallasNE Mar 2020 #58

Animal experiments show the potential for teratogenic effects on fetuses TexasTowelie Mar 2020 #59