Health
Related: About this forumPancreatic cancer cells feed off hyaluronic acid
I have friends that have died from pancreatic cancer, seems like lots of them.
https://labblog.uofmhealth.org/lab-report/pancreatic-cancer-cells-feed-off-hyaluronic-acid?utm_source=newsletter&utm_medium=email&utm_content=Read%20more&utm_campaign=2019-09-16LabWeeklyDigest
Often found in beauty products and wellness supplements, hyaluronic acid attracts and retains water well. Its also a major player in the physiology of pancreatic tumors.
Hyaluronic acid, or HA, is a known presence in pancreatic tumors, but a new study from researchers at the University of Michigan Health Rogel Cancer Center shows that hyaluronic acid also acts as food to the cancer cells. These findings, recently published in eLife, provide insight into how pancreatic cancer cells grow and indicate new possibilities to treat them.
A central driving theme in my research lab is that pancreatic cancer doesn't respond to the common arsenal of treatment approaches. We need to think about this challenge differently, said Costas Lyssiotis, Ph.D., the lead investigator on the study. He and his team study the metabolism of pancreatic cancer in preclinical models: how cells obtain nutrients and the spectrum of nutrients they utilize to fuel growth and enable therapeutic resistance.
The tumor microenvironment, or the cells that make up the tumor, are a combination of many different cell types, some malignant, some not. A pancreatic tumors microenvironment is highly stromal, meaning the mass itself is mostly comprised of connective tissue and non-cancerous immune cells.
Phoenix61
(17,649 posts)no_hypocrisy
(48,812 posts)Some are tablets, some are capsules, and some are gels.
I wonder if it's the capsules or the plastic that the stuff is encased in.
I never considered one could create cancer from trying to stay healthy.
I wish the article had more information about what it meant by "wellness supplements".
jaxexpat
(7,794 posts)A: If it's NOT likely to have been in the available human diet for millennia, it is suspect.
A-1: Especially suspect if it's advertised and promoted to aid health.
Tree Lady
(12,205 posts)If I feel anything coming on I take zinc and Vitamin D for a few days.
StClone
(11,869 posts)I take Vitamin D every day as well as Q10. My dentist recommended this years ago for gum health-it seems to work. And if you have healthy gums it seems your overall health is good!
Tree Lady
(12,205 posts)Just bought a waterpik flossing back teeth is harder for me. I wasn't very good with my teeth when younger so getting better habits now.
jaxexpat
(7,794 posts)Too many gums held irresponsibly is a recipe for disaster. I think we need some laws with teeth.
niyad
(119,939 posts)MLAA
(18,602 posts)ToxMarz
(2,246 posts)I would be more concerned about that than something applied to the skin, but I'm not a doctor so who knows.
MLAA
(18,602 posts)Thanks for the heads up. I usually read ingredients closely because I dont want to eat any animal products, it it never occurred to me to look for HA. I will have to be more vigilant!
ToxMarz
(2,246 posts)But people inject it for wrinkles and joint pain, take it as a supplement in pill form and other things that would be more concentrated than what might absorb through the skin.
multigraincracker
(34,080 posts)I hope they find something else that can counter the bad effects.
wnylib
(24,405 posts)multigraincracker
(34,080 posts)BComplex
(9,078 posts)too.
I'm glad these scientists are looking into it, however. There's been a big jump in pancreatic cancers in North Carolina....people I know, not statistically.
multigraincracker
(34,080 posts)Skin products.
wnylib
(24,405 posts)There be more pancreatic cancers than there are?
multigraincracker
(34,080 posts)Looks like the best hope is to find something to reduce affect on that organ and keep the healthy part.
Not sure I'd avoid it now.
live love laugh
(14,410 posts)that local clusters might have other causes.
It would be interesting to see if any cluster areas also had identified sources of HA.
KarenS
(4,634 posts)Wicked Blue
(6,655 posts)which contains rose hip oil and hyaluronic acid. Thank goodness I rarely bothered using it.
Thank you for posting this information!
multigraincracker
(34,080 posts)Hope this helps.
https://labblog.uofmhealth.org/lab-report/cell-hunters-starving-pancreatic-cancer-by-targeting-cell-metabolism
Cell Hunters: Starving Pancreatic Cancer by Targeting Cell Metabolism
Comprehending how pancreatic tumor cells thrive might be the key to new therapies and diagnostic tools.
HariSeldon
(500 posts)...was "Ooh, something preferentially consumed by cancer cells? Can we make it radioactive or oncotoxic?"
question everything
(48,811 posts)nilram
(2,979 posts)Its about using this newly-discovered nutrient pathway for drug development. My mom died from pancreatic cancer but Im not gonna worry about any HA that I might put on my skin or eat in my food.
bucolic_frolic
(46,998 posts)https://www.verywellhealth.com/hyaluronic-acid-supplements-89465
Readily available, topical and orally. Somebody gonna do some 'splainin'?
7 foods high in HA
https://www.healthline.com/nutrition/hyaluronic-acid-diet
FailureToCommunicate
(14,325 posts)products mentioned. Just awful luck, it seemed, in his case.
TNNurse
(7,125 posts)But one study does not validate a result.
Caution is of course a good idea, but lets see what other studies show.
One inaccurate study did a lot of anti-vaccine harm.
Again, not disputing the results, it needs more study.
multigraincracker
(34,080 posts)Lots more info to go with it.
ananda
(30,820 posts)I don't use skincare prodcuts, but I do eat healthy
foods and won't stop just because of that.
I think we need some hyaluronic acid in our diets,
but not overly much maybe.
multigraincracker
(34,080 posts)liberalla
(10,018 posts)I haven't read the whole article... this is just my immediate reaction to the headline...
I will read it on my break.
multigraincracker
(34,080 posts)See post #11 for that one. Puts some perspective with the first one.
hibbing
(10,402 posts)multigraincracker
(34,080 posts)in the last few years.
hibbing
(10,402 posts)Layzeebeaver
(1,866 posts)Butter was good once, then it became bad
Butter replacements were then good. Now they appear to be getting a bad rap.
Now butter is back to being good.
This is only one example - it also depends on what companies are sponsoring the research and what conclusions they are trying to get to support their product advertising and sales.
It sounds like the HA is a component of the pancreas tumor cell ecosystem - not like it causes the cancer - but it might be a help to the tumor cells and their survival. It is therefore being researched as a drug delivery vector that could target the cancer cells directly and selectively.
This is a good news story not a doom and gloom moment.
Carry on with your supplements and beauty serums. As soon as there is statistical data to prove a cancer link THEN hit the panic switch and order a special trash pick up.
nilram
(2,979 posts)Its about a pathway they are trying to exploit. Maybe they can attach a poison to HA, for instance.
TexLaProgressive
(12,287 posts)Summary
In PDAC tissues, HA is secreted from tumor cells and stromal cells through upregulation of HAS in response to tumorstroma interactions. The secreted HA, or its smaller fragments, may promote tumor cell proliferation, migration, invasion, and angiogenesis through HA‐receptor signaling and also serve as a barrier to access of chemotherapeutic agents to tumor cells. Given these links of HA with cancer progression, targeting HA represents a potential therapeutic approach for treatment of PDAC. There are different approaches of HA‐targeted therapies that include strategies aimed at inhibiting HA synthesis, blocking HA‐receptor signaling, and depleting stromal HA (Fig. Fig.33).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970823/
NNadir
(34,664 posts)Hyaluronic acid is naturally synthesized in human tissue, of which it is an essential component.
It is a naturally occurring anino sugar polymer.
It is not simply a dietary supplement.
multigraincracker
(34,080 posts)Looks more like a path to more research to get a cure for cancer. From the same University.
hippywife
(22,767 posts)what they use to inject patient's knees when they lose the all cushioning cartilage in them? I saw an article about these injections a long time ago, hoping that they would also be able to inject them into the ankle, but so far no luck.