The Covid-19 Plasma Boom Is Over. What Did We Learn From It?

[Eugene]

Source: New York Times

The Covid-19 Plasma Boom Is Over. What Did We Learn From It?

The U.S. government invested $800 million in plasma when the country was desperate for Covid-19 treatments. A year later, the program has fizzled.

By Katie Thomas and Noah Weiland
April 17, 2021

-snip-

But by the end of the year, good evidence for convalescent plasma had not materialized, prompting many prestigious medical centers to quietly abandon it. By February, with cases and hospitalizations dropping, demand dipped below what blood banks had stockpiled. In March, the New York Blood Center called Mr. Cohen to cancel his 12th appointment. It didn’t need any more plasma.

A year ago, when Americans were dying of Covid at an alarming rate, the federal government made a big bet on plasma. No one knew if the treatment would work, but it seemed biologically plausible and safe, and there wasn’t much else to try. All told, more than 722,000 units of plasma were distributed to hospitals thanks to the federal program, which ends this month.

The government’s bet did not result in a blockbuster treatment for Covid-19, or even a decent one. But it did give the country a real-time education in the pitfalls of testing a medical treatment in the middle of an emergency. Medical science is messy and slow. And when a treatment fails, which is often, it can be difficult for its strongest proponents to let it go.

Because the government gave plasma to so many patients outside of a controlled clinical trial, it took a long time to measure its effectiveness. Eventually, studies did emerge to suggest that under the right conditions, plasma might help. But enough evidence has now accumulated to show that the country’s broad, costly plasma campaign had little effect, especially in people whose disease was advanced enough to land them in the hospital.

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Read more: https://www.nytimes.com/2021/04/17/health/covid-convalescent-plasma.html

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Short excerpt from a long article. Among the important points: Convalescent plasma has some benefits if used early. Beware of "pandemic exceptionalism" short circuiting science. The injection of politics was unhelpful.

[intrepidity]

1. And then there's this

In a recent interview, he said that Mr. Trump’s involvement in the plasma authorization had made the topic polarizing.

“Any discussion one could have about the science and medicine behind it didn’t happen, because it became a political issue as opposed to a medical and scientific one,” Dr. Hahn said.

That toxic dump did that to many topics, didn't he?

[Warpy]

2. In the early days of the disease, it was all they had to go on

but once patients were ill enough to be in the hospital, too much damage had been done to them to make the treatment particularly effective. The virus did clear, but the damage persisted and there was little effect of survivability.

Convalescent plasma has been well known to mitigate disease, but it has to be given early, before the targeted body system(s) have been too badly damaged.

The whole mess was compounded by the fact that Dumdum considered himself to be the only expert worth listening to.